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Medchemexpress LLC Lobeline hydrochloride | 134-63-4 | 99.97% | 10 MM * 1 ML
SDP

Supplier:  Medchemexpress LLC HYB097910MM/1ML

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Lobeline hydrochloride, a brain-penetrant nicotinic receptor agonist, increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles and altering presynaptic DA storage. It is effective in smoking cessation and has potential in methamphetamine-related disorder research.

  • Acts as a brain-penetrant nicotinic receptor agonist.
  • Increases dopamine release by inhibiting its uptake into synaptic vesicles.
  • Alters presynaptic dopamine storage.
  • Effective for smoking cessation.
  • Evokes dopamine overflow calcium-independently (0.1-100 μM).
  • Inhibits dopamine uptake into synaptosomes (IC50=80 μM) and vesicles (IC50=0.88 μM).
  • Decreases d-methamphetamine self-administration in rats.
  • Decreases d-methamphetamine responding and increases tolerance development.
  • Supplied as a 10 mM solution in 1 mL of water.

Catalog No. 50-004-09113


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