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Apexbio Technology LLC Lofexidine (hydrochloride) 21498-08-8 1g
Supplier: Apexbio Technology LLC C39901000
Lofexidine hydrochloride (CAS 21498-08-8) is a selective 2-adrenergic receptor agonist demonstrating high affinity for the 2A-receptor subtype By activating presynaptic 2-adrenergic autoreceptors in the central nervous system lofexidine modulates noradrenergic neurotransmission which is implicated in opioid withdrawal physiology Following oral administration lofexidine is extensively absorbed with peak plasma concentrations achieved within approximately 3 hours Clinically it has been investigated for the management of opioid withdrawal symptoms with reported adverse effects including insomnia dry mucous membranes sedation dizziness and asthenia Lofexidine serves as a research tool in studies of adrenergic receptor pharmacology and opioid detoxification
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