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Medchemexpress LLC Lomeguatrib | 192441-08-0 | 99.8% | 326.17 | 100 MG
Supplier: Medchemexpress LLC HY13668100MG
Lomeguatrib is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor. It exhibits an IC50 of 9 nM in cell-free assays and 6 nM in MCF-7 cells.
- Acts as an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor.
- Shows an IC50 of 9 nM in cell-free assays.
- Exhibits an IC50 of 6 nM in MCF-7 cells.
- Increases the growth inhibitory effects of temozolomide in MCF-7 cells.
- Completely inactivates MGMT within 2 hours at 20 mg/kg i.p.
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