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Medchemexpress LLC Lometrexol | 106400-81-1 | 99.0% | C21H25N5O6 | 1 MG
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Supplier:  Medchemexpress LLC HY145211MG

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Lometrexol (DDATHF) is an antipurine antifolate that inhibits glycinamide ribonucleotide formyltransferase (GARFT) and de novo purine synthesis. It causes abnormal cell proliferation, apoptosis, and cell cycle arrest. Lometrexol exhibits anticancer activity and is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. It binds tightly to GART, depleting intracellular purine ribonucleotides.

  • Antipurine antifolate
  • Inhibits GARFT activity
  • Inhibits de novo purine synthesis
  • Induces abnormal cell proliferation and apoptosis
  • Causes cell cycle arrest
  • Exhibits anticancer activity
  • Potent hSHMT1/2 inhibitor
  • Depletes intracellular purine ribonucleotides

Catalog No. 50-003-54294


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