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Medchemexpress LLC Lomitapide | 182431-12-5 | 99.6% | 693.72 | 200 MG
Supplier: Medchemexpress LLC HY14667200MG
Lomitapide is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro. Intended for research use only, it undergoes hepatic metabolism via cytochrome P-450 (CYP) isoenzyme 3A4 and interacts with CYP3A4 substrates. It has been shown to reduce plasma concentrations of low-density lipoprotein cholesterol (LDL-C) by more than 50%.
- Target: microsomal triglyceride-transfer protein (MTP)
- IC50: 8 nM (MTP) in vitro
- Metabolism: hepatic metabolism via cytochrome P-450 (CYP) isoenzyme 3A4
- Bioavailability: 7.1% for the 50-mg capsule
- Half-life: 39.7 hours
- Appearance: white to off-white solid
- Powder storage: -20°C for 3 years, 4°C for 2 years
- Solvent storage: -80°C for 2 years, -20°C for 1 year
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