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Medchemexpress LLC Lomitapide | 182431-12-5 | 99.6% | 693.72 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY14667

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Lomitapide is a potent inhibitor of microsomal triglyceride-transfer protein (MTP), demonstrating an IC50 of 8 nM in vitro.

  • Inhibits microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
  • Reduces plasma concentrations of low density lipoprotein cholesterol (LDL-C) and triglycerides.
  • Indicated for the treatment of Homozygous Familial Hypercholesterolemia (HoFH).
  • Metabolized via cytochrome P-450 (CYP) isoenzyme 3A4.
  • Bioavailability of 7.1% and a mean half-life of 39.7 hours for the 50-mg capsule.
  • Exhibits antiproliferative activity against human HepG2 cells.
  • Appears as a solid, white to off-white substance.

Catalog No. 50-003-63286


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