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Loperamide hydrochloride, Tocris Bioscience™

Catalog No. 08401G
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Catalog No. Quantity
08-401-G 1 g
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Catalog No. 08-401-G Supplier R&D Systems Supplier No. 0840/1G
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Description

Peripherally acting μ agonist; Ca2+ channel blocker

High affinity μ-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels.

Chemical Identifiers

CAS 34552-83-5
Molecular Formula C29H34Cl2N2O2
Molecular Weight (g/mol) 513.503
InChI Key PGYPOBZJRVSMDS-UHFFFAOYSA-N
Synonym loperamide hydrochloride, loperamide hcl, imodium, suprasec, dissenten, fortasec, lopemid, lopemin, loperyl, imosec
PubChem CID 71420
ChEBI CHEBI:6533
IUPAC Name 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide;hydrochloride
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl

Specifications

Quantity 1 g
Formula Weight 513.51
Percent Purity >99%
Chemical Name or Material Loperamide hydrochloride

Safety and Handling

Recommended Storage Store at Room Temperature
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