Apexbio Technology LLC Lopinavir 192725-17-0 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A82045.1

Lopinavir is an inhibitor targeting the human immunodeficiency virus (HIV) protease enzyme implicated in viral polyprotein cleavage and maturation Structurally analogous to ritonavir lopinavir binds to HIV protease and suppresses catalytic activity consequently blocking HIV replication It demonstrates potent inhibitory actions against both wild-type and protease-inhibitor-resistant HIV variants Reported inhibition constants (Ki) for lopinavir range between 1 3 and 3 6 pM with antiviral efficacy represented by an EC50 below 0 06 M against protease mutants such as Val82 variants Due to its low susceptibility to inhibition by human serum proteins lopinavir is frequently utilized in antiviral screening assays drug-resistance research and investigations into HIV enzymology and resistance mechanisms

Catalog No. 50-000-62159