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AdipoGen Lopinavir (250 mg)
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Supplier:  AdipoGen AGCR13715M250

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Chemical. CAS: 192725-17-0. Formula: C37H48N4O5. MW: 628.8. The antiviral agent Lopinavir is a potent inhibitor of HIV-1 protease (Ki=1.3pM for wild-type enzyme) and has been shown to block the replication of clinical isolates of HIV (EC50s=5-52nM). Lopinavir is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24). It also has been shown to inhibit meningioma cell proliferation, induce apoptosis on lymphoma cells and inhibit insulin signaling. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the coronavirus endopeptidase C30 (CEP_C30) of SARS-CoV-2. A initial randomized trial study was not successful.

Catalog No. 50-205-4102


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