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Enzo Life Sciences Lorcainide. HCl (10mg). CAS: 58934-46-6
Supplier: Enzo Life Sciences BMLNA1430010
Possesses both local anesthetic and antiarrhythmic properties (class 1C agent). Elevates the ventricular fibrillation threshold and protects against ouabain-induced arrhythmias in animal models. Its mechamism of action is primarly inhibition of sodium channels in a voltage- and frequency-dependent fashion. Also inhibits the microsomal Na+,K+-ATPase in a concentration-dependent manner (IC50=33.5µM) . Reduces neuronal death in cellular models of hypoxic injury when combined with a glutamate receptor antagonist and blocks aconitine-induced mortality in a rat model (ED50=30mg/kg). Alternative name: N-(4-Chlorophenyl)-N-[1-(1-isopropyl)-4-piperidinyl]phenylacetamide . HCl. Purity: ≥98% (TLC). Solubility: Soluble in water (>30mg/ml), DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Long Term Storage: Ambient.
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