Medchemexpress LLC Losartan Carboxylic Acid | 124750-92-1 | 99.5% | 10 MG

Supplier:  Medchemexpress LLC HY1276510MG

Losartan Carboxylic Acid (E-3174) is an active carboxylic acid metabolite of Losartan, functioning as an angiotensin II receptor type 1 (AT1) antagonist. It blocks angiotensin II-induced responses in vascular smooth muscle cells and elevates plasma renin activities while reducing mean arterial pressure.

• Blocks angiotensin II-induced responses in vascular smooth muscle cells.
• Elevates plasma renin activities.
• Reduces mean arterial pressure.
• Inhibits specific binding of angiotensin II to vascular smooth muscle cells with an IC50 of 1.1 nM.
• Abolishes angiotensin II-induced formation of inositolphosphates in vascular smooth muscle cells.
• Inhibits angiotensin II-induced elevation of intracellular cytosolic Ca2+ concentration with an IC50 of 5 nM.
• Inhibits angiotensin II-induced cell protein synthesis with an IC50 of 3 nM.
• Induces an 87±4% inhibition of pressor responses to angiotensin I in mongrel dogs at 0.1 mg/kg.

Catalog No. 50-003-40868