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Apexbio Technology LLC Losmapimod 585543-15-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B46205.1
Losmapimod (CAS 585543-15-3) also known as GW856553 is a selective orally bioavailable inhibitor of p38 mitogen-activated protein kinase (MAPK) It exhibits potent inhibitory activity against p38 and p38 isoforms with reported pKi values of 8 1 and 7 6 respectively By inhibiting p38 MAPK a kinase essential in inflammatory signaling pathways and cytokine production Losmapimod has demonstrated beneficial effects in preclinical and clinical models It improves nitric oxide-mediated vasodilation and reduces markers of systemic inflammation such as C-reactive protein and fibrinogen This molecule is utilized in research studies addressing inflammation-driven cardiovascular disorders hypercholesterolemia and chronic obstructive pulmonary disease (COPD)
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