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Apexbio Technology LLC Lovastatin 75330-75-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A43655.1
Lovastatin (CAS 75330-75-5) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) a rate-controlling enzyme in cholesterol biosynthesis that mediates conversion of HMG-CoA to mevalonate In vitro assays show that lovastatin inhibits HMG-CoA reductase activity with IC50 values of 2 3 nmol/L in rat hepatocytes and 5 nmol/L in human hepatoma HepG2 cells By decreasing mevalonate and subsequent isoprenoid intermediates lovastatin reduces cellular proliferation and DNA synthesis It also enhances macrophage-mediated clearance of apoptotic cells at concentrations around 5 M Lovastatin serves as a useful tool in studies investigating lipid metabolism cellular proliferation pathways and related inflammatory processes
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