Thermo Scientific Chemicals Lovastatin, 98%

Description

Lovastatin, CAS # 75330-75-5, is a cholesterol lowering compound and inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. | CAS: 75330-75-5 | C24H36O5 | 404.55 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Applications

• It blocks product ion of mevalonate, a critical compound in the production of cholesterol and isoprenoids

• It can increase cellular resistance to anticancer agents such as doxorubicin • It can induce apoptosis in myeloma cells

• It can cause cell cycle arrest in G1 and G2/M phase

• It also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF

Specifications

Chemical Identifiers

• CAS: 75330-75-5
• Molecular Formula: C24H36O5
• Molecular Weight (g/mol): 404.55
• MDL Number: MFCD00072164
• InChI Key: PCZOHLXUXFIOCF-BXMDZJJMSA-N
• Synonym: lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin
• PubChem CID: 53232
• ChEBI: CHEBI:40303
• IUPAC Name: [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
• SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

• Melting Point: 175.0°C
• Infrared Spectrum: Authentic
• Assay Percent Range: 97.5% min. (HPLC)
• Quantity: 5 g
• Solubility Information: Solubility in water: insoluble. Other solubilities: less soluble in ethanol, soluble in chloroform and acetone
• Formula Weight: 404.54
• Percent Purity: 98%
• Chemical Name or Material: Lovastatin

Safety and Handling

Hazard Category	GHS Signal Word: Warning
Hazard Statement	GHS H Statement May cause an allergic skin reaction. Suspected of causing cancer. Suspected of damaging the unborn child.
Precautionary Statement	GHS P Statement Wear protective gloves/protective clothing. IF ON SKIN: Wash with plenty of soap and water. Obtain special instructions before use. IF exposed or concerned: Get medical advice/attention.

SDS

RUO – Research Use Only