AdipoGen Loxistatin acid

Supplier:  AdipoGen AGCP37007M001

Chemical. CAS 76684-89-4. Formula C15H26N2O5. Molecular Weight 314.4. E-64c is a potent cell-impermeable epoxysuccinyl peptide inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B, H and L. Does not inhibit the serine proteases trypsin, chymotrypsin or elastase. E-64c is an active metabolite of the protease inhibitor E-64d Prod. No. AG-CR1-3737, and a synthetic analog of E-64 Prod. No. AG-CP3-7006. Studies indicate that E-64c is a more potent inhibitor of cathepsins B and L compared to E-64. E-64c has in vitro antiviral, antiparasitic and immunomodulatory properties. It reduces the autocatalytic activity of the foot-and-mouth-disease virus FMDV leader protease, reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with SARS-CoV spike glycoprotein in a concentration-dependent manner, inhibits human rotavirus replication, and exhibits entry-blocking effects against MERS-CoV.

Catalog No. 50-256-2405