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Medchemexpress LLC LP-261 | 915412-67-8 | 99.9% | C22H19N3O4S | 50 MG
Supplier: Medchemexpress LLC HY1438950MG
LP-261 is a potent, orally active anti-mitotic agent that inhibits tubulin polymerization in vitro with an EC50 of 3.2 μM. It has shown the ability to inhibit the growth of human non-small-cell lung tumors (NCI-H522) in vivo and is used in cancer research.
- Potent and orally active anti-mitotic agent.
- Inhibits tubulin polymerization in vitro.
- Shows potent G2/M block activity in various cell lines (MCF-7, H522, Jurkat, SW-620, BXPC-3, and PC-3) with IC50 values ranging from 0.01 μM to 0.38 μM.
- Effectively inhibits tumor growth in a human non-small-cell lung tumor xenograft model in NCr-nu mice, with a 96% reduction in mean tumor volume at 50 mg/kg.
- Displays rapid oral adsorption with a Tmax of 2.0 hours in rats.
- Exhibits moderate elimination rate with a terminal half-life of 1.4 hours in rats.
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