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Medchemexpress LLC LP-533401 hydrochloride | 1040526-12-2 | 99.4% | 562.94 | 5 MG
Supplier: Medchemexpress LLC 5MGHY15849A
LP-533401 hydrochloride is an inhibitor of tryptophan hydroxylase 1, an enzyme that regulates the production of serotonin in the gut. It is intended for research use only. Studies have shown that this compound can inhibit serotonin production in Tph1-expressing cells. When administered orally to rodents, it dose-dependently prevents and rescues osteoporosis by increasing bone formation. Pharmacokinetic studies suggest that it has negligible brain penetration.
- Negligible brain penetration after oral administration in rodents.
- Reduces 5-HT content in the gut, lungs, and blood of mice.
- Increases osteoblast numbers and inhibits the decrement in trabecular bone volume in mice.
- Can be dissolved in DMSO for in vitro studies.
- Protocols for in vivo dissolution in various solvent mixtures are available.
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