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Medchemexpress LLC LP17 TFA (LQVTDSGLYRCVIYHPP TFA) | 99.2% | 1961.24 | 5 MG
Supplier: Medchemexpress LLC HYP3400A5MG
LP17 (LQVTDSGLYRCVIYHPP) TFA is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. It substantially alleviates ischemia-induced infarction and neuronal injury by accessing the brain and blocking TREM-1. For research use only.
- Decreases mRNA levels of pro-inflammatory cytokines and chemokines.
- Attenuates extracellular protein levels of IL-1β and IL-18 in a microglia oxygen-glucose deprivation (OGD) model.
- Interacts with microglial SYK.
- Alleviates ischemia-induced infarction and neuronal injury in mice.
- Reduces infarct volume by 27.3%.
- Reduces TUNEL positive cells and FJC positive neurons.
- Rescues neurological deficits and cognitive dysfunction.
- Inhibits microglial M1 polarization and neutrophil infiltration.
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