AdipoGen LPP pAb IG-817

Supplier:  AdipoGen AG25T0106C050

Polyclonal Antibody. Recognizes human, rat and pig LPP. Source Rabbit. Applications ICC, IP, WB. Liquid. In PBS containing 0.01% sodium azide. Lipoma preferred partner LPP is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP thyroid receptor interacting protein 6 / ZRP-1 zyxin-related protein 1, LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains double zinc finger structures that are involved in protein-protein interactions.

Catalog No. 50-256-3167