Invivogen Biotinylated TLR4 Agonist | 500 µg

Supplier:  Invivogen TLRLLPSBIOT

LPS-EB Biotin is biotinylated ultrapure lipopolysaccharide (LPS) from the Gram-negative bacteria E. coli 0111:B4. LPS is recognized by toll-like receptor 4 (TLR4) which interacts with three different extracellular proteins: LPS binding protein (LBP), CD14 and, myeloid differentiation protein 2 (MD-2), to induce a signaling cascade leading to the activation of NF-κB and the production of proinflammatory cytokines. Most LPS preparations on the market are contaminated by other bacterial components, such as lipoproteins, thus activating TLR2 signaling as well as TLR4 signaling. The ultrapure preparation that InvivoGen provides only activates the TLR4 pathway. In this product, biotin has been bound to LPS’s oxidized-carbohydrates using biotin-LC-hydrazide as previously described. The labeled ligand retains the biological activity of LPS. LPS‑EB Biotin can be used for the detection of LPS binding sites by cytometry or fluorescence microscopy.

Catalog No. NC1838287