AdipoGen LPS from E. coli O8:K27 (S-form) TLRpure Sterile Solution

Supplier:  AdipoGen IAX100006M001

LPS from E. coli O8:K27 (S-form) TLRpure Sterile Solution, AdipoGen Life Sciences. Chemical. MW: . Isolated and purified from E. coli O8:K27. Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal interaction with LPS, TLR4 requires association with myeloid differentiation protein 2 (MD-2). According to current consensus activation of TLR4 is preceded by the transfer of LPS to membrane-bound (m) or soluble (s) CD14 by LPS-binding protein (LBP). Re-form LPS and lipid A, but not S-form LPS, are capable of inducing TNF-alpha responses also in the absence of CD14. LPS, synthesized by most wild-type (WT) Gram-negative bacteria (S-form LPS), consists of three regions, the O-polysaccharide chain, which is made up of repeating oligosaccharide units, the core oligosaccharide and the lipid A, which harbors the endotoxic activity of the entire molecule.

Catalog No. 50-596-693