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AdipoGen LRP5 6 mAb recHeldy-1-4
SDP

Supplier:  AdipoGen AG27B0019C100

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Recombinant Antibody. Recognizes human and mouse LRP5 & LRP6. Species cross-reactivity Human, Mouse. Clone Heldy-1-4. Isotype Human IgG2lambda. Applications FACS. Host HEK 293 cells. Liquid. In PBS containing 10% glycerol. Wnt/beta-catenin signaling acts as a regulator of tissue development and homeostasis. Wnt ligands bind to a member of the Frizzled family of seven-transmembrane proteins and to either highly homologous low-density lipoprotein related receptors 5 LRP5 or LRP6. Low-density lipoprotein receptor-related protein 6 LRP6 is a member of the low-density lipoprotein receptor LDLR family. LRP5 and LRP6 are expressed in most human tissues and is composed of three distinctive cell-surface protein domains, including 1 LDL receptor LDLR type A repeats 2 an epidermal growth factor EGF-like domain and 3 a YWTD Tyr-Trp-Thr-Asp-type beta propeller domain. LRP6 is inhibited by the Dickkopf protein Dkk1 bound to their partners Kremen.

Catalog No. 50-256-3149


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