Thermo Scientific™ LRRK2 [G2019S] Recombinant Protein

Catalog No.	Quantity
A15200	10 μg
A15202	1 mg

Catalog No. A15200 Supplier Thermo Scientific™ Supplier No. A15200

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots; aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease. Increase disease relevance by interrogating a purified and active full-length LRRK2 protein Uncover novel compounds or hits specific to the full-length form Advance Parkinson's research using the full-length protein and validated assays Related Links: LRRK2 tools for advancing Parkinson's disease research Kinase protein portfolio LanthaScreen™ Eu Kinase Binding Assay LanthaScreen™ TR-FRET Kinase Activity Assay Protein Form: Recombinant, Full Length, Mutant.

LRRK2 (Leucine Rich Repeat Kinase 2) is a Protein Coding gene. Diseases associated with LRRK2 include Parkinson Disease 8, Autosomal Dominant and Hereditary Late-Onset Parkinson Disease. Among its related pathways are Signaling by PTK6 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma. Gene Ontology (GO) annotations related to LRRK2 (G2019S Mutant) include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of LRRK2 (G2019S Mutant) is TNNI3K. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease.

Specifications

• Accession Number: Q5S007
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris with 0.5mM EDTA, 150mM NaCl, 50% glycerol, 0.02% Triton X-100, 2mM DTT and no preservative; pH 7.5
• Gene ID (Entrez): 120892
• Molecular Weight (g/mol): 288 kDa
• Name: LRRK2 [G2019S]
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: LRRK2
• Common Name: LRRK2 (G2019S Mutant)
• Gene Symbol: LRRK2
• KinaseFamily: LRRK Kinase Family
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: DYKDDDDK-tag
• Sequence: Full length
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Expression System: proprietary
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Full Length, Mutant
• Form: Liquid
• Research Category: Neurobiology

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov