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AdipoGen LTbetaR ms mAb 4H8 WH2
Supplier: AdipoGen AG20B0008C100
Monoclonal Antibody. Recognizes mouse LTbetaR. Isotype Rat IgG2a. Clone 4H8 WH2. Applications FACS, FUNC Blocking. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB relA/p50 pathway, like the type 1 TNF receptor TNFR1, that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
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