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Apexbio Technology LLC Lu AE58054 Hydrochloride 467458-02-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A35615.1
Lu AE58054 Hydrochloride (CAS 467458-02-2) is a potent and selective antagonist of the serotonin 5-HT6 receptor exhibiting high affinity with a Ki of 0 83 nM It displays over 50-fold selectivity for 5-HT6 receptors compared to more than 70 other targets with moderate affinity for 1A and 1B adrenergic receptors Functional assays demonstrate that Lu AE58054 Hydrochloride effectively inhibits 5-HT-mediated activation of 5-HT6 receptors In rodent studies oral administration blocks radioligand binding to 5-HT6 receptors and reverses cognitive impairment induced by phencyclidine This compound is widely employed in research to investigate cognitive deficits associated with disorders such as Alzheimer s disease and schizophrenia
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