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Cayman Chemical LumIracoxIb 100mg
Supplier: Cayman Chemical 27645100 MG
A selective inhibitor of COX-2 over COX-1 (IC50s = 0.13 and 67 µM, respectively); reduces increases in the levels of PGE2 induced by IL-1β in human dermal fibroblasts (IC50 = 0.14 µM), as well as in LPS-stimulated RAW 264.7 cells at 1-100 µM; decreases LPS-induced increases in the levels of PGE2 in a rat model of air pouch inflammation at 3 and 10 mg/kg; reduces M. tuberculosis-induced increases in hind paw volume and the radiological and histopathological severity of arthritic lesions in a rat model of chronic arthritis at 2 mg/kg
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