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Cayman Chemical LumIracoxIb 100mg
SDP

Supplier:  Cayman Chemical 27645100 MG

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A TRPV4 antagonist (IC50s 2 3 5 9 and 3 2 UM for human mouse and rat respectively) selective for TRPV4 over TRPV1 TRPV3 and TRPM8 (IC50s 100 30 and 30 UM respectively) reduces GSK1016790A-induced increases in IGly from 34 5 to 0 97 in mouse hippocampal neurons in vitro (10 UM) blocks GSK1016790A-induced arteriolar dilation and increases myogenic tone in rat cremaster arterioles ex vivo (30 UM) reduces edema and MAPK signaling induced by traumatic brain injury in rats (1 mg/kg i p ) inhibits breakdown of the blood-retinal barrier in streptozotocin-induced diabetic rats (100 UM)

Catalog No. 50-293-9795


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