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Medchemexpress LLC Lurasidone | 367514-87-2 | 99.4% | C28H36N4O2S | 200 MG
SDP

Catalog No. 5000432178
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Lurasidone is an antagonist of both dopamine D2 and 5-HT7 receptors with IC50s of 1.68 nM and 0.495 nM, respectively. It also acts as a partial agonist of the 5-HT1A receptor with an IC50 of 6.75 nM. In vitro, it shows higher affinity for dopamine D2 and 5-HT2A receptors compared to other tested antipsychotics.

  • Antagonist of dopamine D2 and 5-HT7 receptors
  • Partial agonist of the 5-HT1A receptor
  • Dose-dependently increases the ratio of DOPAC/dopamine in frontal cortex and striatum
  • Inhibits conditioned avoidance response (CAR) in rats
  • Inhibits tryptamine (TRY)-induced forepaw clonic seizure and p-chloroamphetamine (p-CAMP)-induced hyperthermia

Catalog No. 50-004-32178 Supplier Medchemexpress LLC Supplier No. HYB0032A200MG
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Lurasidone is an antagonist of both dopamine D2 and 5-HT7 receptors with IC50s of 1.68 nM and 0.495 nM, respectively. It also acts as a partial agonist of the 5-HT1A receptor with an IC50 of 6.75 nM. In vitro, it shows higher affinity for dopamine D2 and 5-HT2A receptors compared to other tested antipsychotics.

  • Antagonist of dopamine D2 and 5-HT7 receptors
  • Partial agonist of the 5-HT1A receptor
  • Dose-dependently increases the ratio of DOPAC/dopamine in frontal cortex and striatum
  • Inhibits conditioned avoidance response (CAR) in rats
  • Inhibits tryptamine (TRY)-induced forepaw clonic seizure and p-chloroamphetamine (p-CAMP)-induced hyperthermia

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