Medchemexpress LLC Lurasidone | 367514-87-2 | 99.4% | C28H36N4O2S | 500 MG

Supplier:  Medchemexpress LLC HYB0032A500MG

Lurasidone is an antagonist of both dopamine D2 and 5-HT7 receptors with IC50s of 1.68 nM and 0.495 nM, respectively. It is also a partial agonist of the 5-HT1A receptor with an IC50 of 6.75 nM.

• Antagonizes dopamine D2 and 5-HT7 receptors.
• Acts as a partial agonist of the 5-HT1A receptor.
• Exhibits higher affinity for dopamine D2 and 5-HT2A receptors.
• Inhibits dopamine-stimulated [35S]GTPγS binding.
• Increases DOPAC/dopamine ratio in frontal cortex and striatum.
• Comparable potency to olanzapine in inhibiting conditioned avoidance response.
• Inhibits tryptamine-induced forepaw clonic seizure and p-chloroamphetamine-induced hyperthermia.
• Increases shocks received by rats in conflict test.

Catalog No. 50-004-32882