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Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 5 MG
SDP

Catalog No. 5000415975
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Luteolin 7-O-glucuronide is a compound that inhibits Matrix Metalloproteinases (MMP) activities, with specific IC50 values for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13. It also demonstrates biological activity by inhibiting NO production and the mRNA expression of various inflammatory mediators, as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In vivo studies suggest it can improve depression-like and stress coping behaviors in sleep-deprived mice models.

  • Inhibits matrix metalloproteinases (MMPs) activities
  • Inhibits NO production in LPS-stimulated RAW 264.7 macrophages
  • Reduces mRNA expression of inflammatory mediators
  • Suppresses NF-κB, p38, and JNK activation
  • Improves depression-like and stress coping behaviors in sleep deprivation models
  • Decreases immobility time and plasma corticosterone levels
  • Enhances BDNF mRNA expression in the hippocampus

Catalog No. 50-004-15975 Supplier Medchemexpress LLC Supplier No. HYN14635MG
May include imposed supplier surcharges.
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Luteolin 7-O-glucuronide is a compound that inhibits Matrix Metalloproteinases (MMP) activities, with specific IC50 values for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13. It also demonstrates biological activity by inhibiting NO production and the mRNA expression of various inflammatory mediators, as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In vivo studies suggest it can improve depression-like and stress coping behaviors in sleep-deprived mice models.

  • Inhibits matrix metalloproteinases (MMPs) activities
  • Inhibits NO production in LPS-stimulated RAW 264.7 macrophages
  • Reduces mRNA expression of inflammatory mediators
  • Suppresses NF-κB, p38, and JNK activation
  • Improves depression-like and stress coping behaviors in sleep deprivation models
  • Decreases immobility time and plasma corticosterone levels
  • Enhances BDNF mRNA expression in the hippocampus

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