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Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 5 MG
Supplier: Medchemexpress LLC HYN14635MG
Luteolin 7-O-glucuronide is a compound that inhibits Matrix Metalloproteinases (MMP) activities, with specific IC50 values for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13. It also demonstrates biological activity by inhibiting NO production and the mRNA expression of various inflammatory mediators, as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In vivo studies suggest it can improve depression-like and stress coping behaviors in sleep-deprived mice models.
- Inhibits matrix metalloproteinases (MMPs) activities
- Inhibits NO production in LPS-stimulated RAW 264.7 macrophages
- Reduces mRNA expression of inflammatory mediators
- Suppresses NF-κB, p38, and JNK activation
- Improves depression-like and stress coping behaviors in sleep deprivation models
- Decreases immobility time and plasma corticosterone levels
- Enhances BDNF mRNA expression in the hippocampus
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