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Medchemexpress LLC Luxeptinib | 1616428-23-9 | 99.0% | 495.43 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY139535100MG

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Luxeptinib (CG-806) is an orally active, reversible, first-in-class, non-covalent and potent pan-FLT3/pan-BTK inhibitor. It induces cell cycle arrest, apoptosis, or autophagy in acute myeloid leukemia cells.

  • Inhibits proliferation of MEC-1 CLL cells with an IC50 of 32 nM.
  • Suppresses SYK phosphorylation in primary chronic lymphocytic leukemia (CLL) cells.
  • Completely inhibits phosphorylation of FLT3 and STAT5 in MV4-11 cells.
  • Undergoing phase 1 clinical trials for chronic lymphocytic leukemia, small lymphocytic lymphoma, and non-Hodgkin´s lymphoma.
  • Undergoing phase 1 clinical trials for acute myeloid leukemia and myelodysplastic syndromes.

Catalog No. 50-003-51552


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