Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC LV-320 | 2449093-46-1 | 95.0% | 520.11 | 1 ML
Supplier: Medchemexpress LLC HY11271110MM/1ML
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5 μM and a Kd of 16 μM. It inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic, and active in vivo.
- Increases endogenous LC3B-II and protein p62 levels in SKBR3, MCF7, JIMT1, and MDA-MB-231 cells in a dose-dependent manner.
- Blocks autophagic flux in MDA-MB-231 cells.
- Achieves terminal blood levels of 169 μM and liver levels of 104 μM in GFP-LC3 mice following oral gavage.
- Significantly increases the accumulation of GFP-LC3 puncta and LC3B-II protein in treated animals without causing significant toxicity at tested doses.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?