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Apexbio Technology LLC LX-1031 945976-76-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A35655.1
LX-1031 (CAS 945976-76-1) is an orally administered small-molecule inhibitor of tryptophan hydroxylase (TPH) the rate-limiting enzyme in peripheral serotonin (5-HT) biosynthesis As a heterocyclic phenylalanine analogue LX-1031 selectively reduces 5-HT synthesis outside the central nervous system In vitro LX-1031 suppresses TPH1 activity within nanomolar concentration ranges In animal studies oral administration leads to dose-dependent reductions in jejunal 5-HT levels Clinical investigations have demonstrated that LX-1031 lowers urinary 5-hydroxyindoleacetic acid (5-HIAA) reflecting decreased peripheral serotonin turnover LX-1031 is under investigation for disorders characterized by elevated peripheral 5-HT such as diarrhea-predominant irritable bowel syndrome
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