Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC LXR-623 875787-07-8 10mg
Supplier: Apexbio Technology LLC B126410
LXR-623 (CAS 875787-07-8) is a small-molecule partial agonist targeting liver X receptors LXR- and LXR- It selectively activates LXR- and LXR- modulating cholesterol homeostasis by regulating gene expression involved in cholesterol transport LXR-623 exerts its biological activity primarily through induction of cholesterol transporters such as ABCA1 and ABCG1 enhancing cholesterol efflux and reverse cholesterol transport In animal models oral administration of LXR-623 increases expression of ABCA1 and ABCG1 in peripheral blood cells and intestinal ABCG5/ABCG8 in mouse atherosclerosis models with reported IC50 values of 24 nM for LXR- and 179 nM for LXR- Based on these pharmacological properties LXR-623 holds research potential in atherosclerosis and Alzheimer s disease
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?