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Apexbio Technology LLC LY 294002 154447-36-6 10mg
Supplier: Apexbio Technology LLC A825010
LY294002 (CAS 154447-36-6) is a cell-permeable selective reversible inhibitor of class I phosphatidylinositol 3-kinases (PI3Ks) It targets the ATP binding pocket of PI3K catalytic subunits p110 p110 and p110 showing IC50 values of 500 nM 973 nM and 570 nM respectively LY294002 inhibits PI3K-dependent signaling pathways involving Akt mTOR and cell survival regulator Bad thereby inducing apoptosis suppressing tumor cell proliferation and impairing autophagosome formation Additionally LY294002 inhibits BET bromodomain proteins BRD2 BRD3 and BRD4 (IC50 1 2 M) It is commonly utilized as a pharmacological tool to investigate PI3K signaling mechanisms and autophagy regulation
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