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Enzo Life Sciences LY 294002 (5 mg). CAS: 154447-36-6
Supplier: Enzo Life Sciences BMLST4200005
Potent, cell permeable, inhibitor of PI(3)K (phosphoinositide 3-kinase) that acts on the ATP-binding site of the enzyme. Displays an IC50 of 1.4µM and inhibits all isoforms equally in in vitro assays using purified PI 3-kinase (p110α IC50=0.63µM). Inhibits Pim-1 kinase with IC50=4.0µM. Other kinases such as PKC, PKA, MAP kinase, S6 kinase, EGF receptor tyrosine kinase, c-src kinase, PI 4-kinase, diacylglycerol kinase or rabbit kidney ATPase are not inhibited at 50µM. Induces apoptosis in many cell types by blocking the PI3-K/Akt anti-apoptotic pathway. Useful tool for identifying cellular events which are regulated by the PI3-K/Akt axis. Sensitizes tumor cells to drug-induced apoptosis independent of its PI3K inhibitory activity. Alternative name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25mg/ml, warm), 100% ethanol (25mg/ml, warm) or methanol. Long Term Storage: -20°C.
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