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Apexbio Technology LLC LY2109761 700874-71-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A84645.1
LY2109761 (CAS 700874-71-1) is a selective small-molecule inhibitor targeting type I and type II transforming growth factor-beta (TGF- ) receptors (T RI/II) with Ki values of 38 nM and 300 nM respectively Acting through ATP-binding site competition in the TGF- receptor I kinase domain (IC50 69 nM) LY2109761 inhibits downstream signaling pathways implicated in tumor development and metastasis In preclinical studies LY2109761 reduced proliferation migration invasion and promoted apoptosis across various cancer cell types including pancreatic carcinoma glioblastoma and myelomonocytic leukemia It also lowered radiotherapy-induced pulmonary fibrosis in animal models illustrating its broad research utility
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