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Cayman Chemical LY2228820mesylate 10mg
Supplier: Cayman Chemical 2325910 MG
A potent inhibitor of p38α MAP kinase (IC50 = 7 nM for human recombinant p38α); inhibits LPS-induced TNF-α production in murine peritoneal macrophages and reduces phosphorylation of MK2 in RAW 264.7 cells (IC50s = 5.2 and 34.3 nM, respectively); inhibits TNF-α production in LPS-treated mice and reduces paw swelling and cartilage destruction in a rat model of chronic inflammation (TMED50s = <1, 1.5, and 1.5 mg/kg, respectively)
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