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Cayman Chemical LY2365109hydrochlorIde 50mg
SDP

Supplier:  Cayman Chemical 3742750 MG

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An inhibitor of LAT1 (IC50 0.14 M for 14C-leucine uptake in S2 cells expressing the human transporter) selective for LAT1 over LAT2 (IC50 10 M) inhibits 14C-leucine uptake by and growth of HT-29 cells (IC50s 0.06 and 4.1 M respectively) induces apoptosis and increases levels of cleaved caspase-3 caspase-7 caspase-9 and PARP in YD-38 oral cancer cells at 3 mM reduces tumor growth in an HT-29 mouse xenograft model at 6.3 12.5 and 25 mg/kg

Catalog No. 50-291-6164


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