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Cayman Chemical LY2365109hydrochlorIde 50mg
Supplier: Cayman Chemical 3742750 MG
An inhibitor of GlyT1a (IC50 = 15.8 nM in BE2-C cells expressing the human transporter); selective for GlyT1a over GlyT2 (IC50 = >30 µM in RD cells expressing the human transporter); induces locomotor hyperactivity, impaired gait, compulsive walking, and labored breathing, as well as impairs the ability to stand, in rats at 10 mg/kg; prevents maximal electroshock-induced acute seizures in mice at 30 mg/kg and decreases seizure number in an electroshock-induced rat model of chronic epilepsy at 10 mg/kg
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