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Apexbio Technology LLC LY2603618 911222-45-2 200mg
Supplier: Apexbio Technology LLC A8638200
LY2603618 (CAS 911222-45-2) is a small-molecule inhibitor selectively targeting checkpoint kinase 1 (Chk1) an enzyme responsible for orchestrating DNA damage repair pathways It competitively binds Chk1 s ATP-binding domain thereby inhibiting its kinase activity Experimental studies in non-small cell lung cancer cell lines (including A549 and H1299) demonstrated that treatment with LY2603618 induced DNA damage increased -H2AX phosphorylation and resulted in G2/M phase cell cycle arrest In vivo assessments using Calu-6 lung cancer xenograft models indicated enhanced DNA damage response when combined with gemcitabine chemotherapy LY2603618 is employed as a valuable tool in cancer research to explore Chk1 s biological role and evaluate synergistic therapeutic strategies
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