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Apexbio Technology LLC LY2784544 1229236-86-5 200mg
Supplier: Apexbio Technology LLC A4147200
LY2784544 (CAS 1229236-86-5) is a potent and selective ATP-competitive inhibitor of JAK2 tyrosine kinase exhibiting an IC50 of 3 nM It demonstrates 8-fold and 16-fold selectivity over JAK1 and JAK3 respectively In cellular assays LY2784544 effectively inhibits STAT5 phosphorylation in Ba/F3-TEL-JAK2 cells (IC50 0 191 nM) while displaying substantially reduced activity against JAK1 and JAK3-dependent STAT5 phosphorylation The compound suppresses proliferation and induces apoptosis in cells harboring the JAK2 V617F mutation In murine models it reduces tumor burden and strongly inhibits STAT5 phosphorylation in JAK2 V617F-driven cells LY2784544 is a valuable tool for studying JAK2-mediated signaling and myeloproliferative neoplasms
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