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Apexbio Technology LLC LY2874455(Synonyms: LY-2874455, LY 2874455, FGFR inhibitor LY2874455, Fibroblast growth factor receptor inhibitor LY2874455), 5mg, CAS: 1254473-64-7.
Supplier: Apexbio Technology LLC A35765
LY2874455 (CAS 1254473-64-7) is a small molecule inhibitor targeting fibroblast growth factor receptors (FGFRs) proteins functioning through ligand-induced receptor dimerization and tyrosine kinase activation By blocking FGFR phosphorylation and downstream signaling pathways LY2874455 inhibits proliferation and migration in FGFR-dependent cancer cell models LY2874455 shows inhibition of FGFR phosphorylation in FGFR1- FGFR2- and FGFR3-expressing cancer cell lines and xenografts demonstrating antitumor efficacy across various FGFR-driven tumor types It serves as a valuable tool molecule in oncology research investigating FGFR-mediated cancers
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