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STEMCELL Technologies LY294002, Size: 5 mg
Supplier: STEMCELL Technologies 72152
LY294002 is a PI3K inhibitor that has greater potency and selectivity than quercetin, the structure on which it is based. LY294002 inhibits PI3K (IC₅₀ = 1.4 µM) and also shows activity against CK2, but not PI4K, EGFR, PDGFR, MAPK, PKA, or PKC. (Davies et al., Vlahos et al.)MAINTENANCE AND SELF-RENEWAL· Suppresses proliferation and self-renewal of mouse embryonic stem (ES) cells (Lianguzova et al., Paling et al.).DIFFERENTIATION· Promotes differentiation to insulin-producing cells from mouse ES cells (Hori et al.).· Inhibits myotube formation from myoblasts (Coolican et al., Jiang et al.).
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