Cayman Chemical LY294002hydrochlorIde 10mg

Supplier:  Cayman Chemical 3917110 MG

A multi-kinase inhibitor; inhibits CK2 (IC50 = 0.098 µM), the PI3K subunits p110α, p110β, p110δ, and p110γ (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA-PK (IC50 = 6 µM), among other kinases, as well as CK1, GSK3α, and GSK3β by greater than 40% at 10 µM; inhibits LPS-induced activation of NF-κB in a reporter assay using RAW 264.7 macrophages at 20 µM; induces apoptosis and autophagy in SGC-7901 cells at 50 µM; reduces tumor volume in DLD-1 and LoVo mouse xenograft models at 2 ng/ml/kg; reduces aging-induced increases in the number of aging SA-β-gal-positive human VSMCs at 20 µM in the 5th to 15th generations

Catalog No. 50-291-8271