Medchemexpress LLC LY3020371 hydrochloride | 1377615-44-5 | 99.2% | 395.81 | 5 MG

Supplier:  Medchemexpress LLC 5MGHY123820

LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM. It exerts an antidepressant-like signature in vivo.

• Potent, selective mGlu2/3 receptor antagonist.
• Ki values of 5.3 nM for mGluR2 and 2.5 nM for mGluR3.
• Blocks cAMP formation with an IC50 of 16.2 nM.
• Exerts an antidepressant-like signature in vivo.
• Blocks agonist-suppressed Ca2+ oscillations (IC50=34 nM) and in hippocampal slices (IC50=46 nM).
• Intravenous injection leads to effective mGlu2/3 receptor blockade in rat cerebrospinal fluid.
• Promotes wakefulness, reducing NREM sleep in Wistar rats.
• Available in various sizes and forms.
• High purity (99.18%).
• Detailed documentation provided.
• Solubility and dissolution protocols available.

Catalog No. 50-003-64389