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Medchemexpress LLC LY3020371 hydrochloride | 1377615-44-5 | 99.2% | 395.81 | 5 MG
SDP

Catalog No. 5000364389
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LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM. It exerts an antidepressant-like signature in vivo.

  • Potent, selective mGlu2/3 receptor antagonist.
  • Ki values of 5.3 nM for mGluR2 and 2.5 nM for mGluR3.
  • Blocks cAMP formation with an IC50 of 16.2 nM.
  • Exerts an antidepressant-like signature in vivo.
  • Blocks agonist-suppressed Ca2+ oscillations (IC50=34 nM) and in hippocampal slices (IC50=46 nM).
  • Intravenous injection leads to effective mGlu2/3 receptor blockade in rat cerebrospinal fluid.
  • Promotes wakefulness, reducing NREM sleep in Wistar rats.
  • Available in various sizes and forms.
  • High purity (99.18%).
  • Detailed documentation provided.
  • Solubility and dissolution protocols available.

Catalog No. 50-003-64389 Supplier Medchemexpress LLC Supplier No. 5MGHY123820
May include imposed supplier surcharges.
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LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM. It exerts an antidepressant-like signature in vivo.

  • Potent, selective mGlu2/3 receptor antagonist.
  • Ki values of 5.3 nM for mGluR2 and 2.5 nM for mGluR3.
  • Blocks cAMP formation with an IC50 of 16.2 nM.
  • Exerts an antidepressant-like signature in vivo.
  • Blocks agonist-suppressed Ca2+ oscillations (IC50=34 nM) and in hippocampal slices (IC50=46 nM).
  • Intravenous injection leads to effective mGlu2/3 receptor blockade in rat cerebrospinal fluid.
  • Promotes wakefulness, reducing NREM sleep in Wistar rats.
  • Available in various sizes and forms.
  • High purity (99.18%).
  • Detailed documentation provided.
  • Solubility and dissolution protocols available.

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