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Cayman Chemical LY456236hydrochlorIde 10mg
Supplier: Cayman Chemical 4226310 MG
An antagonist of mGluR1 (IC50 = 140 nM); reduces the growth of PC-9 cells and PC-9-AMG cells in MGS co-culture but not in monoculture; reduces MGS co-culture-induced increases in EGFR levels in PC-9-AMG cells; reduces tumor growth in a PC-9-AMG mouse model of brain metastasis at 50 mg/kg per day; inhibits seizures in a variety of seizure models, including inhibition of audiogenic clonic-tonic seizures in mice (ED50 = 35 mg/kg); reduces second-phase, but not first-phase, formalin-induced hyperalgesia at 30 and 100 mg/kg
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