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Medchemexpress LLC LYG-409 | 3053857-55-6 | 98.1% | 515.44 | 5 MG
Supplier: Medchemexpress LLC HY1709525MG
LYG-409 is an orally active degrader of GSPT1. It demonstrates excellent anti-acute myeloid leukemia and prostate cancer activity in vivo, with TGI percentages of 94.34% and 104.49%, respectively. In vitro, it inhibits KG-1 cells through the degradation of GSPT1, showing an IC50 of 9.50 nM and a DC50 of 7.87 nM.
- Orally active degrader of GSPT1.
- Exhibits anti-acute myeloid leukemia and prostate cancer activity in vivo.
- Inhibits KG-1 cells by degrading GSPT1.
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