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Medchemexpress LLC Lys-CoA TFA | 98.5% | 50 MG
SDP

Supplier:  Medchemexpress LLC HY13103550MG

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Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). Lys-CoA TFA effectively inhibits p300 HAT activity-dependent transcriptional activation.

  • Selective p300 histone acetyltransferase (HAT) inhibitor
  • Displays >100-fold selectivity for p300 over PCAF
  • Inhibits p300 HAT activity-dependent transcriptional activation
  • Induces a senescent phenotype in human normal melanocytes at concentrations of 0.1 and 1 mM over 60 hours
  • Almost completely abolished proliferation, induced high levels of SA-β-Gal, and inhibited cyclin E expression in a dose-dependent manner in normal human melanocytes
  • For research use only

Catalog No. 50-003-40679


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