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AdipoGen m-3M3FBS
SDP

Supplier:  AdipoGen AGCR13548M010

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Chemical. CAS 200933-14-8. Formula C16H16F3NO2S. MW 343.4. m-3M3FBS is a cell permeable and specific activator of phospholipase C PLC that has been shown to stimulate the PLC-mediated intracellular Ca2 release, inositol phosphates production and superoxide generation in various cell types. It activates all PLC isotypes beta2, beta3, gamma1, gamma2 and delta1 in vitro, but not heterotrimeric G proteins, PI 3-kinase or PLD. m-3M3FBS also affects calcium homeostasis independently of PLC activation. m-3M3FBS induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling. m-3M3FBS has been shown in vitro to trigger mitochondrial damage and activate NLRP10 a bona fide inflammasome binding to Asc and Caspase-1 in keratinocytes. NLRP10 acts also as inflammasome in intestine epithelial cells and protects against autoinflammation in the gut.

Catalog No. 50-256-2304


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