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Medchemexpress LLC M-89 | 2363165-42-6 | 99.1% | 10 MG
SDP

Supplier:  Medchemexpress LLC HY12834710MG

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M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to study MLL leukemia. M-89 inhibits the cell growth in leukemia cell lines carrying MLL fusion.

  • Inhibits the cell growth of MV4-11 cell line with an IC50 of 25 nM.
  • Inhibits the cell growth of HL-60 cell line with an IC50 of 10.2 μM.
  • Stabilized the cellular menin protein in both MV4-11 and MOLM-13 cells dose-dependently (3.7-300 nM).
  • Induces a time- and dose-dependent apoptosis in MV4-11 cells (0.03-3 μM, 48 h).

Catalog No. 50-003-39745


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