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Genscript Corporation Antibody Protein Proteins Proteins 1 MG 1/EA
Supplier: Genscript Corporation Z029141
Macrophage-Colony Stimulating Factor (M-CSF) also known as Colony Stimulating Factor-1 (CSF-1) is a hematopoietic growth factor. It can stimulate the survival proliferation and differentiation of mononuclear phagocytes in addition to the spreading and motility of macrophages. In mammals it exits three isoforms which invariably share an N-terminal 32-aa signal peptide a 149-residue growth factor domain a 21-residue transmembrane region and a 37-aa cytoplasmictail. M-CSF is mainly produced by monocytes macrophages fibroblasts and endothelial cells. M-CSF interaction with its receptor c-fms has been implicated in the growth invasion and metastasis of of several diseases including breast and endometrial cancers. The biological activity of human M-CSF is maintained within the 149-aa growth factor domain and it is only active in the disulfide-linked dimeric form which is bonded at Cys63.
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